Il nostro contributo

L’impatto scientifico misura l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un istituto di ricerca. Per IFOM, l’impatto scientifico non si limita solo alla quantità di pubblicazioni, ma si estende alla qualità delle riviste su cui vengono pubblicati i nostri studi, alla visibilità dei nostri risultati e alla capacità di trasformare queste scoperte in avanzamenti concreti nella lotta contro il cancro.

Avolio M, Leto SM, Sassi F, Lupo B, Grassi E, Catalano I, Zanella ER, Vurchio V, Cottino F, Tsantoulis PK, Lazzari L, Luraghi P, Ferri M, Galimi F, Berrino E, Bellomo SE, Viviani M, Sogari A, Mauri G, Tosi F, Cruciani F, Sartore-Bianchi A, Siena S, Borghi F, Torri V, Élez E, Tabernero J, Nieva M, Montagut C, Tarazona N, Cervantes A, Tejpar S, Bardelli A, Marchiò C, Marsoni S, Bertotti A, Trusolino L

The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer.

Cancer Discov 2026; 270-295. doi: 10.1158/2159-8290.CD-24-0556

Eli S, Rauso G, Ghezzi P, Szczerkowski JLA, Bruzzi M, Rizzelli F, Iommazzo F, Loffreda A, Castagna F, Donà F, Gaddoni C, Dondi A, Marenda M, Rodighiero S, Tournier P, Lavagnino Z, Parazzoli D, Gauthier NC, Tamburri S, Pasini D, Habib SJ, Mapelli M

Localized Wnt-signaling promotes asymmetric NuMA-dependent oriented divisions and unequal apportioning of mitochondria.

Nat Commun 2025; 10690. doi: 10.1038/s41467-025-65775-z

Ponzo M, Drufuca L, Buracchi C, Sindoni MM, Nucera S, Bugarin C, Bason R, Rossetti G, Bonnal R, Meli C, Rambaldi B, Lussana F, Ferrari S, Moretti A, Dastoli G, Risca G, Pellegrino C, Manz MG, Galimberti S, Rambaldi A, Gaipa G, Biondi A, Pagani M, Magnani CF

Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.

J Immunother Cancer 2025; . doi: 10.1136/jitc-2025-011768

Alaimo A, Carbone FG, Buzo K, Annesi N, Genovesi S, Lorenzato A, Widmann K, Libergoli M, Marmocchi E, Bertalot G, Brolese A, Papotti MG, Molinaro L, Caffo O, Barbareschi M, Bardelli A, Romanel A, Arena S, Lunardi A

TRPM8 levels determine tumor vulnerability to channel agonists.

Mol Oncol 2025; 2905-2920. doi: 10.1002/1878-0261.70049

Vitiello PP, Valsecchi AA, Duregon E, Di Celle PF, Cassoni P, Papotti M, Bardelli A, Di Maio M

KRAS G12C Inhibition in Solid Tumors: Biological Breakthroughs, Clinical Evidence, and Open Challenges.

Cancers (Basel) 2025; . doi: 10.3390/cancers17172803

Brunet L, Alexandre D, Lee J, Blanquer-Rosselló MDM, Bracquemond D, Guernet A, Chhouri H, Goupil M, Kherrouche Z, Arabo A, Mancini M, Cartier D, Yao S, Godefroy D, Dehedin J, Li JR, Duparc C, Jamme P, Vinchent A, Bérard C, Tulasne D, Arena S, Bardelli A, Cheng C, Cho BC, Wurtz O, Coulouarn C, Maraver A, Aaronson SA, Cortot AB, Anouar Y, Grumolato L

Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells.

Nat Commun 2025; 7853. doi: 10.1038/s41467-025-61788-w

D'Oria C, Cincinelli G, Bason R, Pisati F, Simoncello F, Scotti I, Giudice L, Suardi I, Ferrua P, Fossati C, Randelli PS, Caporali R, Pagani M, Ingegnoli F

Patient-Derived Explants of Osteoarthritic Synovium as Ex Vivo Model for Preclinical Research.

Int J Mol Sci 2025; . doi: 10.3390/ijms26146665

Marasco M, Kumar D, Garcia Borrego S, Seale T, Maddalena G, Mezzadra R, Belanger K, Cole S, Perez B, Luan W, Mukherjee R, Aricescu I, Markov V, Zhu Y, Arena S, Bardelli A, de Stanchina E, Lowe SW, Burkhart RA, Zimmerman JW, Yaeger R, Kopetz SE, Rosen N, Misale S

Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.

Cancer Discov 2025; 1392-1409. doi: 10.1158/2159-8290.CD-24-0614

Grassi E, Vurchio V, Cresswell GD, Catalano I, Lupo B, Sassi F, Galimi F, Borgato S, Ferri M, Viviani M, Pompei S, Urgese G, Chen B, Zanella ER, Cottino F, Russo M, Mauri G, Pietrantonio F, Zampino MG, Lazzari L, Marsoni S, Bardelli A, Lagomarsino MC, Sottoriva A, Trusolino L, Bertotti A

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer.

Sci Transl Med 2025; eado1641. doi: 10.1126/scitranslmed.ado1641

Alcon C, Kovatcheva M, Morales-Sánchez P, López-Polo V, Torres T, Puig S, Lu A, Samitier J, Enrich C, Serrano M, Montero J

HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells.

Cell Death Differ 2025; 646-656. doi: 10.1038/s41418-024-01417-z

Stier AB, Bonaiuti P, Juhász J, Gross F, Ciliberto A

lncreased risk of slippage upon disengagement of the mitotic checkpoint.

PLoS Comput Biol 2025; e1012879. doi: 10.1371/journal.pcbi.1012879

Bonilla-Quintana M, Ghisleni A, Gauthier NC, Rangamani P

Dynamic mechanisms for membrane skeleton transitions.

J Cell Sci 2025; . doi: 10.1242/jcs.263473

Protasoni M, López-Polo V, Stephan-Otto Attolini C, Brandariz J, Herranz N, Mateo J, Ruiz S, Fernandez-Capetillo O, Kovatcheva M, Serrano M

Cyclophilin D plays a critical role in the survival of senescent cells.

EMBO J 2024; 5972-6000. doi: 10.1038/s44318-024-00259-2

Pham VC, Rödel CJ, Valentino M, Malinverno M, Paolini A, Münch J, Pasquier C, Onyeogaziri FC, Lazovic B, Girard R, Koskimäki J, Hußmann M, Keith B, Jachimowicz D, Kohl F, Hagelkruys A, Penninger JM, Schulte-Merker S, Awad IA, Hicks R, Magnusson PU, Faurobert E, Pagani M, Abdelilah-Seyfried S

Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations.

EMBO Mol Med 2024; 2827-2855. doi: 10.1038/s44321-024-00152-9

Pessei V, Macagno M, Mariella E, Congiusta N, Battaglieri V, Battuello P, Viviani M, Gionfriddo G, Lamba S, Lorenzato A, Oddo D, Idrees F, Cavaliere A, Bartolini A, Guarrera S, Linnebacher M, Monteonofrio L, Cardone L, Milella M, Bertotti A, Soddu S, Grassi E, Crisafulli G, Bardelli A, Barault L, Di Nicolantonio F

DNA demethylation triggers cell free DNA release in colorectal cancer cells.

Genome Med 2024; 118. doi: 10.1186/s13073-024-01386-5

Russo M, Chen M, Mariella E, Peng H, Rehman SK, Sancho E, Sogari A, Toh TS, Balaban NQ, Batlle E, Bernards R, Garnett MJ, Hangauer M, Leucci E, Marine JC, O'Brien CA, Oren Y, Patton EE, Robert C, Rosenberg SM, Shen S, Bardelli A

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities.

Nat Rev Cancer 2024; 694-717. doi: 10.1038/s41568-024-00737-z

López-Polo V, Maus M, Zacharioudakis E, Lafarga M, Attolini CS, Marques FDM, Kovatcheva M, Gavathiotis E, Serrano M

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells.

Nat Commun 2024; 7378. doi: 10.1038/s41467-024-51363-0

Valentino M, Malinverno M, Maderna C, Pham VC, Rödel CJ, Zanardi F, Arce M, Drufuca L, Rossetti G, Magnusson PU, Lampugnani MG, Dejana E, Abdelilah-Seyfried S, Pagani M

BMI1 Inhibition Improves Lesion Burden in Cerebral Cavernous Malformations.

Circulation 2024; 738-741. doi: 10.1161/CIRCULATIONAHA.123.067438

Hanthi YW, Ramirez-Otero MA, Appleby R, De Antoni A, Joudeh L, Sannino V, Waked S, Ardizzoia A, Barra V, Fachinetti D, Pellegrini L, Costanzo V

RAD51 protects abasic sites to prevent replication fork breakage.

Mol Cell 2024; 3026-3043.e11. doi: 10.1016/j.molcel.2024.07.004

Roa P, Foglizzo V, Harada G, Repetto M, Kulick A, de Stanchina E, de Marchena M, Auwardt S, Sayed Ahmed S, Bremer NV, Yang SR, Feng Y, Zhou C, Kong N, Liang R, Xu H, Zhang B, Bardelli A, Toska E, Ventura A, Drilon A, Cocco E

Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents.

Br J Cancer 2024; 601-610. doi: 10.1038/s41416-024-02760-1

Ghisleni A, Bonilla-Quintana M, Crestani M, Lavagnino Z, Galli C, Rangamani P, Gauthier NC

Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex.

Nat Commun 2024; 5711. doi: 10.1038/s41467-024-49906-6

Oguchi A, Suzuki A, Komatsu S, Yoshitomi H, Bhagat S, Son R, Bonnal RJP, Kojima S, Koido M, Takeuchi K, Myouzen K, Inoue G, Hirai T, Sano H, Takegami Y, Kanemaru A, Yamaguchi I, Ishikawa Y, Tanaka N, Hirabayashi S, Konishi R, Sekito S, Inoue T, Kere J, Takeda S, Takaori-Kondo A, Endo I, Kawaoka S, Kawaji H, Ishigaki K, Ueno H, Hayashizaki Y, Pagani M, Carninci P, Yanagita M, Parrish N, Terao C, Yamamoto K, Murakawa Y

An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases.

Science 2024; eadd8394. doi: 10.1126/science.add8394

Mariella E, Grasso G, Miotto M, Buzo K, Reilly NM, Andrei P, Vitiello PP, Crisafulli G, Arena S, Rospo G, Corti G, Lorenzato A, Cancelliere C, Barault L, Gionfriddo G, Linnebacher M, Russo M, Di Nicolantonio F, Bardelli A

Transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer.

Mol Oncol 2024; 1460-1485. doi: 10.1002/1878-0261.13622

López L, Morosi LG, La Terza F, Bourdely P, Rospo G, Amadio R, Piperno GM, Russo V, Volponi C, Vodret S, Joshi S, Giannese F, Lazarevic D, Germano G, Stoitzner P, Bardelli A, Dalod M, Pace L, Caronni N, Guermonprez P, Benvenuti F

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors.

Nat Commun 2024; 2280. doi: 10.1038/s41467-024-46685-y

Paroni M, Leccese G, Ranzani V, Moschetti G, Chiara M, Perillo F, Ferri S, Clemente F, Noviello D, Conforti FS, Ferrero S, Karnani B, Bosotti R, Vasco C, Curti S, Crosti MC, Gruarin P, Rossetti G, Conte MP, Vecchi M, Pagani M, Landini P, Facciotti F, Abrignani S, Caprioli F, Geginat J

An Intestinal Th17 Subset is Associated with Inflammation in Crohn's Disease and Activated by Adherent-invasive Escherichia coli.

J Crohns Colitis 2023; 1988-2001. doi: 10.1093/ecco-jcc/jjad119

Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R, Sutherland JD

BioE3 identifies specific substrates of ubiquitin E3 ligases.

Nat Commun 2023; 7656. doi: 10.1038/s41467-023-43326-8

Patelli G, Mauri G, Tosi F, Amatu A, Bencardino K, Bonazzina E, Pizzutilo EG, Villa F, Calvanese G, Agostara AG, Stabile S, Ghezzi S, Crisafulli G, Di Nicolantonio F, Marsoni S, Bardelli A, Siena S, Sartore-Bianchi A

Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer.

Clin Cancer Res 2023; 4530-4539. doi: 10.1158/1078-0432.CCR-23-0079

Rosso I, Jones-Weinert C, Rossiello F, Cabrini M, Brambillasca S, Munoz-Sagredo L, Lavagnino Z, Martini E, Tedone E, Garre' M, Aguado J, Parazzoli D, Mione M, Shay JW, Mercurio C, d'Adda di Fagagna F

Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs.

Nat Commun 2023; 7086. doi: 10.1038/s41467-023-42831-0

Tombari C, Zannini A, Bertolio R, Pedretti S, Audano M, Triboli L, Cancila V, Vacca D, Caputo M, Donzelli S, Segatto I, Vodret S, Piazza S, Rustighi A, Mantovani F, Belletti B, Baldassarre G, Blandino G, Tripodo C, Bicciato S, Mitro N, Del Sal G

Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth.

Nat Commun 2023; 6777. doi: 10.1038/s41467-023-42458-1

Zattarin E, Taglialatela I, Lobefaro R, Leporati R, Fucà G, Ligorio F, Sposetti C, Provenzano L, Azzollini J, Vingiani A, Ferraris C, Martelli G, Manoukian S, Pruneri G, de Braud F, Vernieri C

Breast cancers arising in subjects with germline BRCA1 or BRCA2 mutations: Different biological and clinical entities with potentially diverse therapeutic opportunities.

Crit Rev Oncol Hematol 2023; 104109. doi: 10.1016/j.critrevonc.2023.104109

Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, Trepat X, Parton RG, Geli MI, Scita G, Arroyo M, Le Roux AL, Roca-Cusachs P

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale.

Elife 2023; . doi: 10.7554/eLife.72316

Hershey BJ, Barozzi S, Orsenigo F, Pompei S, Iannelli F, Kamrad S, Matafora V, Pisati F, Calabrese L, Fragale G, Salvadori G, Martini E, Totaro MG, Magni S, Guan R, Parazzoli D, Maiuri P, Bachi A, Patil KR, Cosentino Lagomarsino M, Havas KM

Clonal cooperation through soluble metabolite exchange facilitates metastatic outgrowth by modulating Allee effect.

Sci Adv 2023; eadh4184. doi: 10.1126/sciadv.adh4184

Cortellino S, Quagliariello V, Delfanti G, Blaževitš O, Chiodoni C, Maurea N, Di Mauro A, Tatangelo F, Pisati F, Shmahala A, Lazzeri S, Spagnolo V, Visco E, Tripodo C, Casorati G, Dellabona P, Longo VD

Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects.

Nat Commun 2023; 5529. doi: 10.1038/s41467-023-41066-3

Valenza C, Trapani D, Gandini S, Sposetti C, Boscolo Bielo L, Marra A, Giarratano T, Favero D, Cortesi L, Moscetti L, Pistelli M, Berardi R, Zambelli A, Lambertini M, Del Mastro L, Guarneri V, Vernieri C, Curigliano G

Platinum-based chemotherapy and PARP inhibitors for patients with a germline BRCA pathogenic variant and advanced breast cancer (LATER-BC): retrospective multicentric analysis of post-progression treatments.

Eur J Cancer 2023; 112944. doi: 10.1016/j.ejca.2023.112944

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